CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. As with other broad-spectrum antibiotics, prolonged administration of cefuroxime axetil may result in overgrowth of nonsusceptible microorganisms. If superinfection occurs during therapy, appropriate measures should be taken. Cephalosporins, including cefuroxime axetil, should be given with caution to patients receiving concurrent treatment with potent diuretics because these diuretics are suspected of adversely affecting renal function.
The safety and effectiveness of cefuroxime axetil have not been established in patients with gastrointestinal malabsorption. Patients with gastrointestinal malabsorption were excluded from participating in clinical trials of cefuroxime axetil. Cephalosporins may be associated with a fall in prothrombin activity. Monitor patients for signs and symptoms of bleeding.
Additionally, increased monitoring of the INR, especially during initiation and upon discontinuation of the antibiotic, may be necessary. Animal data show that there are no teratogenic effects of cefuroxime.
There are, however, no adequate and well-controlled studies in pregnant women, Because animal reproduction studies are not always predictive of human response, cefuroxime should be used during pregnancy only if clearly needed.
Cefuroxime is excreted in human breast milk in small quantities; according to the manufacturer, caution should be exercised with use during breast-feeding. Rare potential complications in the nursing infant include alterations of gut flora that might result in diarrhea or related complications e.
Because the risk of serious reactions is relatively rare, the use of many cephalosporins is considered compatible with breast feeding.
Although the use of cefuroxime during breast-feeding has not been evaluated by the American Academy of Pediatrics AAP , other cephalosporins, such as cefazolin, cefprozil, and cefadroxil, are generally considered compatible for use for lactating women by the AAP and other experts. Penicillin-binding proteins are responsible for several steps in the synthesis of the cell wall and are found in quantities of several hundred to several thousand molecules per bacterial cell.
Penicillin-binding proteins vary among different bacterial species. Thus, the intrinsic activity of cefuroxime as well as the other cephalosporins and penicillins against a particular organism depends on their ability to gain access to and bind with the necessary PBP. Like all beta-lactam antibiotics, cefuroxime's ability to interfere with PBP-mediated cell wall synthesis ultimately leads to cell lysis.
Lysis is mediated by bacterial cell wall autolytic enzymes i. Pediatric patients who cannot swallow the tablet whole should receive the oral suspension.
Patients should be counseled that antibacterial drugs, including cefuroxime axetil, should only be used to treat bacterial infections.
They do not treat viral infections e. When cefuroxime axetil is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed.
Skipping doses or not completing the full course of therapy may: The presence of cefuroxime does not interfere with the assay of serum and urine creatinine by the alkaline picrate method. The peak serum cefuroxime concentration after a 1. Carcinogenesis, Mutagenesis, Impairment of Fertility: Although lifetime studies in animals have not been performed to evaluate carcinogenic potential, no mutagenic activity was found for cefuroxime axetil in a battery of bacterial mutation tests.
Important information about excipients Zinnat tablets contain parabens which may cause allergic reactions possibly delayed. Cefuroxime axetil may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives. Cefuroxime is excreted by glomerular filtration and tubular secretion.
Concomitant use of probenicid is not recommended. Concurrent administration of probenecid significantly increases the peak concentration, area under the serum concentration time curve and elimination half-life of cefuroxime. Concomitant use with oral anticoagulants may give rise to increased INR. Studies in animals have shown no harmful effects on pregnancy, embryonal or foetal development, parturition or postnatal development. Zinnat should be prescribed to pregnant women only if the benefit outweighs the risk.
Breastfeeding Cefuroxime is excreted in human milk in small quantities. The safety and effectiveness of cefuroxime axetil have not been established in patients with gastrointestinal malabsorption. Patients with gastrointestinal malabsorption were excluded from participating in clinical trials of cefuroxime axetil.
Cephalosporins may be associated with a fall in prothrombin activity. Those at risk include patients with renal or hepatic impairment or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. Prothrombin time should be monitored in patients at risk and exogenous Vitamin K administered as indicated.
Prescribing cefuroxime axetil tablets in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued.
Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as 2 or more months after having taken the last dose of the antibiotic.
If this occurs, patients should contact their physician as soon as possible. During clinical trials, the tablet was tolerated by pediatric patients old enough to swallow the cefuroxime axetil tablet whole. The crushed tablet has a strong, persistent, bitter taste and should not be administered to pediatric patients in this manner. Pediatric patients who cannot swallow the tablet whole should receive the oral suspension.
Cefuroxime axetil, as with other broad-spectrum antibiotics, should be prescribed with caution in individuals with a history of colitis. No difference in the occurrence of adverse events was found between the 2 regimens. Do not take more of it, do not take it more often, and do not take it for a longer tablet than your doctor ordered. Drugs that Reduce Gastric Acidity Drugs that reduce gastric acidity may result in a lower bioavailability of Cefuroxime Axetil compared with administration in the fasting state. Storage Store at room temperature between degrees F degrees C away from light and moisture. The usual drug of choice in the treatment usp prevention of streptococcal infections, including the prophylaxis of rheumatic fever, is penicillin given by the intramuscular route. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. This includes any possible side effects not listed in this leaflet. Interactions Your healthcare professionals e. Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. Be sure to finish the entire prescription unless your doctor directs you to stop. If you have a kidney problem, your doctor may change your dose, cefuroxime axetil tablets usp 250mg. Axetil with cabergoline bodybuilding buy hypersensitivity to cephalosporin antibiotics. As with other broad-spectrum antibiotics, prolonged administration of cefuroxime axetil may result in overgrowth of nonsusceptible microorganisms. Administration of drugs that reduce gastric acidity may 250mg the cefuroxime effect of increased absorption of Cefuroxime Axetil when administered in the postprandial state. Side Effects Nauseavomitingdiarrheaor stomach pain may occur.
© Copyright 2017 Cefuroxime axetil tablets usp 250mg / Cefuroxime axetil tablets, USP mg: Light blue colored film coated, capsule shaped tablets having “” on one side and “P” on the other side..